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2014学年春季学期系列学术讲座之十
题目：Molecular control of meiosis in fission yeast
报告人：Masayuki Yamamaoto
Director-General, National Institute for Basic Biology, Okazaki, Japan
时间：2014年5月30日（周五），13:00-14:30 PM
地点：威廉希尔一楼邓祐才报告厅
Meiosis is a specialized cellular process that forms haploid gametes from diploid germ cells. Meiosis consists of one round of DNA synthesis followed by two rounds of nuclear division and occurs in all sexually reproducing species to enable the transmission of genetic information to the next generation. Despite its biological significance, however, the molecular mechanisms that underlie meiosis remain largely elusive, particularly in higher organisms. Recent analyses in yeast species have shed new light on the mechanisms underlying the mitosis–meiosis switch. In this seminar I like to discuss the current understanding of these mechanisms in the fission yeast Schizosaccharomyces pombe. This unicellular eukaryote has a number of properties which make it an excellent model system for the study of mitosis–meiosis switching. Meiosis-inducing signals in this microbe, emanating from environmental conditions including the nutrient status, converge on the activity of an RRM-type RNA-binding protein, Mei2. This protein plays pivotal roles in both the induction and progression of meiosis and has now been found to govern the meiotic program in a quite unexpected manner. Fission yeast contains an RNA degradation system (selective elimination system) that removes meiosis-specific mRNAs selectively during the mitotic cell cycle. Mmi1, a novel RNA-binding protein of the YTH-family, is essential for this process. Mei2, in collaboration with a non-coding RNA species named meiRNA, tethers Mmi1 and thereby stabilizes the transcripts necessary for the progression of meiosis. Recent analyses indicate that Mmi1 is involved in not only selective RNA degradation but also facultative heterochromatin formation related to the epigenetic control of gene expression.
Host：孔道春（电话：62760866）
欢迎各位老师和同学积极参加！