IMM & CLS Research Seminar

Title：Decoding the Protein Interaction Networks for Pluripotency and Reprogramming

Speaker：Jianlong Wang, Ph.D.

Mount Sinai School of Medicine, New York, USA

Time：2015年7月31日（星期五）上午11:00-12:00

Place：英国威廉希尔公司英杰交流中心306会议室

Host：英国威廉希尔公司分子医学研究所  汪阳明 (Tel. 6276-6945)

Abstract: Molecular control of the pluripotent state in embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) resides in a core circuitry of master transcription factors Oct4, Sox2 and Nanog that together with other genetic and epigenetic factors form a core regulatory pluripotency network. The homeodomain transcription factor Nanog plays an important role in ESC self-renewal and is essential for acquiring ground state pluripotency during reprogramming. Enforced expression of Nanog liberates ESCs from requisite LIF dependence and reprograms “primed” pluripotent mouse EpiSCs to “naïve” pluripotent ESCs. Understanding how Nanog is transcriptionally regulated and how the Nanog protein orchestrates the genetic and epigenetic events in ESCs/iPSCs is important to further dissect mechanisms of ESC pluripotency and somatic cell reprogramming. I will summarize our studies employing both genomic and proteomic approaches to demonstrate the physical association and functional significance of Nanog with several novel transcriptional and epigenetic regulators in the maintenance and establishment of stem cell pluripotency. I will also present our most recent discovery of a novel pluripotency factor and its mechanistic action in controlling pluripotency and reprogramming.

欢迎各位老师同学积极参加！