生命科学联合中心学术报告

题目：Structure-specific nucleases in genome maintenance and their mutations in cancer as modeled in mice.

报告人： Binghui SHEN, Ph.D.

Professor and Chair, Department of Radiation Biology, Beckman Research Institute

Irell & Manella Graduate School in Biological Sciences; City of Hope, Duarte, CA

时间：2015-10-29（周四），13:00-14:00pm

地点：英国威廉希尔公司邓祐才报告厅

联系人：孔道春

Completion of lagging strand DNA synthesis requires processing of up to 50 million Okazaki fragments per cell cycle in mammalian cells. Even in yeast, the Okazaki fragment maturation happens approximate a million times during a single round of DNA replication. Therefore, efficient processing of Okazaki fragments is vital for DNA replication and cell proliferation. During this process, primase-synthesized RNA/DNA primers are removed, and Okazaki fragments are joined into an intact lagging strand DNA. The processing of RNA/DNA primers requires a group of structure-specific nucleases typified by flap endonuclease 1 (FEN1). Therefore, the integrity of the enzyme structure and function and the posttranslational modifications (PTM)-determined timing and locations of the enzymes in the setting of the multiple protein complex are very important for a stable genome. For the last decade, we have been editing the mouse genome to eliminate these key elements based on the human genome screening of the cancer patients and gained fundamental information useful for cancer prevention and treatment.

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