威廉希尔学术报告

题目：Beyond Regulation of Cell Adhesion: Neurexin Mediates Retinoid Transport to Promote Rhodopsin Maturation

报告人：谢维

Dean of Institute of Life Sciences

Southeast University (东南大学), Nanjing, China

时间：2015-11-27（周五），15:30-16:30pm

地点：金光生命科学大楼311室

联系人：陈金琳（生科强化挑战班）

摘要：

Neurexin is cell adhesion molecule that involves in synapse formation and synaptic regulation. Mutations in the neurexin genes are linked to a number of neurodevelopmental disorders, such as autism. Drosophila neurexin (dnrx) is expressed in nervous system and highly enriched in synaptic regions of the ventral ganglion and brain. DNrx plays important roles in the modulation of synaptic architecture, adhesive interactions between pre- and postsynaptic compartments in vivo, and synaptic transmission, associative with learning and sleeping. Interestingly, it was observed that DNrx was also specifically expressed in the visual system at different developmental stages. Lack of DNrx leads to significantly impaired phototaxis and light sensitivity due to reduced rhodopsin levels. DNrx was found it interacts with apolipoprotein I, a product generated by cleavage of retinoid- and fatty acid-binding glycoprotein that functions in retinoid transport. The interaction between ApoL I and DNrx is critical for the stability of ApoL proteins. Neurexin functions in a synapse-independent way, providing a potential pathological mechanism for autism.

报告人简介：

Dr. Xie got his Ph.D in biochemistry and molecular biology in Nanjing University. After grad school, he began a postdoctoral fellowship in University of Rochester Medical Centerand and later a visiting scholar in Hospital for sick children, Toronto. During which, Dr. Xie has conducted outstanding work on signal transduction. Since he came back to China in 2001, his lab has been focusing on research on neuroligin and neurexin and the related disease, Autism spectrum disorders. So far, his lab has accumulated ample tools and experience in ASD study. Dr. Xie is also the dean of Institute of Life Sciences, Southeast University.

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