生命科学联合中心学术报告

题目：Cello: A programming language for cells.

报告人：Christopher Voigt, Ph.D.

Professor

Department of Biological Engineering

Massachusetts Institute of Technology

时间：2015-12-4（周五），13:00-14:30pm

地点：英国威廉希尔公司邓祐才报告厅

联系人：欧阳颀 北大-清华生命科学联合中心

Computation can be performed in living cells using DNA-encoded circuits that process sensory information and control biological functions. Their construction is time-intensive, requiring manual part assembly and balancing of regulator expression. I will describe a design environment (Cello), in which a user writes Verilog code that is automatically transformed to a DNA sequence. Algorithms build a circuit diagram, assign and connect gates, and simulate performance. Reliable circuit design requires the insulation of gates from genetic context, so that they function identically when used in different circuits. Using Cello, 60 circuits were designed for E. coli (0.88 Mbp of DNA), for which each DNA sequence was built as predicted by the software with no additional tuning. Of these, 45 circuits performed correctly (up to 10 regulators and 55 parts), and across the full set 92% of the output states functioned as predicted. Design automation simplifies the incorporation of genetic circuits into biotechnology projects that require decision-making, control, sensing, or spatial organization.

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