生命科学联合中心学术报告

题目：Nutrient Sensing and metabolic communication.

报告人：Xiaoyong Yang, Ph.D.

Associate Professor

Section of Comparative Medicine and Department of Cellular and Molecular Physiology,

Yale University School of Medicine

时间：2015-12-7（周一），13:00-14:30pm

地点：英国威廉希尔公司邓祐才报告厅

联系人：陈兴 北大-清华生命科学联合中心

Nuclear, cytoplasmic, and mitochondrial proteins are extensively modified by O-linked β-N-acetylglucosamine (O-GlcNAc) moieties. This sugar modification regulates fundamental cellular processes in response to diverse nutritional and hormonal cues. The enzymes O-GlcNAc transferase (OGT) and O-linked b-N acetylglucosaminase (O-GlcNAcase) mediate the addition and removal of O-GlcNAc, respectively. Because aberrant O-GlcNAcylation has broad implications in obesity and diabetes, unraveling the role of O-GlcNAc in metabolic regulation is of emerging importance. I will present our recent discoveries on the roles of protein O-GlcNAcylation in nutrient sensing and metabolic communication between the brain and adipose tissue.

欢迎各位老师同学积极参加！