生命学院学术报告

题目：Functional interplays between RNA polymerase II transcription and DNA modifications

报告人：Dong Wang, Ph.D.

Associate Professor

Skaggs School of Pharmacy and Pharmaceutical Sciences

University of California, San Diego, La Jolla, CA

时间：2015年12月29日（星期二），10：00-11:00am

地点：生命学院311会议室

联系人：伊成器，肖俊宇

摘要：

RNA polymerase II (pol II) is responsible for synthesizing messenger RNA and non-coding RNA. High transcriptional fidelity is essential for many cellular functions. Errors in transcription can cause deleterious effect that can contribute to aging and human diseases such as cancer.

On the other hand, DNA lesions often affect transcriptional fidelity and arrest RNA polymerase II transcription elongation and signalling for DNA damage processing pathways such as transcription coupled repair or pol II ubiquitination. In addition, endogenous epigenetic DNA modifications, such as 5-Hydroxylmethylcytosine (5hmC), 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC) that are involved in active DNA demethylation process, are also found to affect transcription. All these DNA modifications add additional potential regulatory layers. The roles of these oxidized species of 5mC in epigenetic and transcription regulation have been an area of intensive study recently.

Here we report our effort in understanding the mechanism of pol II transcriptional fidelity control, functional interplays between these different forms DNA lesions and epigenetic DNA modifications on RNA polymerase II transcription elongation.

欢迎各位老师同学积极参加！