生命科学联合中心学术报告

题目：Neuroimaging in the new century of the Brain

主讲人：KAMIL UGURBIL, Ph.D.

Professor and director

Center for Magnetic Resonance Research

University of Minnesota Medical School

时间：2016-4-27（周三），13:00-14:00

地点：英国威廉希尔公司金光生命科学大楼101报告厅

邀请人：方方  北大-清华生命科学联合中心

摘要：

A central challenge of the 21st Century is to understand the human brain, not only because we are fascinated by its incredible capabilities but also because increasingly, neuropsychiatric disorders (mental and behavioral disorders plus neurological diseases) dominate the health care burden in all industrialized societies. This challenge has led to major initiatives such the Human Connectome Project and the “Obama” BRAIN Initiative in the US, and the Human Brain Project in Europe.  The US BRAIN Initiative identifies “the analysis of circuits of interacting neurons as being particularly rich in opportunity, with potential for revolutionary advances” [1], and focuses on “accelerating the development of technologies for mapping the circuits of the brain” [1]. In this effort, non-invasive magnetic resonance imaging techniques have evolved as the dominant methodology for the study of human brain, going from early experiments demonstrating relatively course images of activity in the visual cortex to providing detailed information on functional and anatomical connectivity in the mm scale, and mapping the activity of sub-millimeter neuronal ensembles that represent elementary computational units, such as cortical columns with laminar resolution. These non-invasive approaches are complemented by equally promising, photon based neuroimaging techniques for mapping activity in animal models in the meso scale, albeit only in animal models due to their invasive nature. Together these approaches span multiple scales in the intricate organization that underlie brain function, and promise major advances towards understating of the human brain activity in health and disease.

1.  Jorgenson, L.A., et al., The BRAIN Initiative: developing technology to catalyse neuroscience discovery. Philos Trans R Soc Lond B Biol Sci, 2015. 370(1668)

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