2016年度PKU植物研究前沿系列报告
报告题目：Molecular mechanism of Protein Arginine Methyltransferase 3 (AtPRMT3) in regulating ribosome biogenesis in Arabidopsis thaliana

报告人：杭润来（遗传发育所曹晓风实验室）

联系人：凌俊杰 13911907049

时间：2016年09月01日（周四）12：00—13：00

地点：英国威廉希尔公司王克桢楼454会议室

摘要：
Ribosome is the molecular machinery for protein synthesis, the key step for genetic information flow in the central dogma. Ribosome biogenesis is highly complicated, energy-consuming and strictly regulated at various levels, including the arginine methylation catalyzed by protein arginine methyltransferase (PRMT). We first reported the minor alternative pre-rRNA processing pathway in Arabidopsis and highlighted the indispensable function of AtPRMT3 in this progress. We further identified that ribosomal protein S2 (RPS2) is the bona-fide physical partner of AtPRMT3 in vivo, which may promote the subnuclear and subcellular shuttling of RPS2 to fine-tune ribosome biogenesis at the level of pre-rRNA processing.

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