BIOPIC学术报告
Title: Single olfactory sensory neurons transiently express multiple olfactory receptors during development
Speaker: Longzhi Tan
Harvard University.
Department of Chemistry and Chemical Biology
Time:2016-11-15, 3:00pm
Venue: 综合科研楼302会议室
联系人：苏晓东 （62759743）
摘要：
In mammals, each olfactory sensory neuron randomly expresses one, and only one, olfactory receptor (OR) --a phenomenon called the "one-neuron‐one‐receptor" rule. Although extensively studied, this rule was never proven for all ~1,000 OR genes in one cell at once, and little is known about its dynamics. Here, we directly tested this rule by single-cell transcriptomic sequencing of 178 cells from the main olfactory epithelium of adult and newborn mice. To our surprise, a subset of cells expressed multiple ORs. Most of these cells were developmentally immature. Our results illustrated how the "one‐neuron‐one‐receptor" rule may have been established: At first, a single neuron temporarily expressed multiple ORs -- seemingly violating the rule -- and then all but one OR were eliminated. This work provided experimental evidence that epigenetic regulation in the olfactory system selects a single OR by suppressing a few transiently expressed ORs in a single cell during development. In more recent work, we identified two putative repressors of OR genes that may be responsible for silencing ORs in direct response to OR expression.
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