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Understanding and Therapeutically Modulating the Balance of human Treg and Th17 under Inflammation

日期: 2016-11-17
生命学院学术报告
Title:Understanding and Therapeutically Modulating the Balance of human Treg and Th17 under Inflammation
Speaker:Bin Li, Ph.D.
Senior Investigator, 
Shanghai Institute of Immunology
时间:11月22日(星期二)下午1:00-2:30
地点:金光生物楼208会议室
联系人:杨竞
Abstract:
Research in Bin Li`s laboratory mainly focuses on understanding molecular mechanism underlying the functional stability, plasticity and balance of FOXP3+ Regulatory T cells (Treg) and RORgt+ T helper 17 cells (Th17) in inflammatory diseases, as well as their therapeutic modulation, especially by compounds from Chinese Traditional Medicine. By using and developing Treg specifically depletion of key enzymatic subunits of FOXP3 complex animal models, as well as these state-of-art cutting-edge technologies in single cell sequencing and immune cell metabolism, we are revealing the functional role of peripheral tissue-specific Treg cells in vitro and in vivo in health and disease settings. We expect that our original findings will be translational to biomedical industry and be beneficial to human health.
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