生命学院学术报告
题目：JMJD1C, a novel tumor dependency, functions as an essential cofactor for leukemic transcription factors
演讲人：Mo CHEN
Postdoctoral Fellow The Rockefeller University, 
Laboratory of Robert Roeder, New York
时间：2016年12月19日下午15:00-16:00
地点：新生物楼411
Abstract:
Hematopoietic stem cells (HSC) are controlled by the expression of key HSC transcription factors (TFs) that act cooperatively to maintain a balance of self-renewal and differentiation. The functions of key TFs are frequently dysregulated in leukemia by chromosomal translocations or mutations. AML1-ETO (AE), generated by the t(8; 21) translocation, dictates a leukemic program by forming a stable TF/cofactor complex (AETFC) containing several HSC TFs. Here I show that the demethylase JMJD1C functions as a coactivator for AETFC and is required for its transcriptional regulation. I also show a critical role for JMJD1C in the survival of multiple human AML cell lines, suggesting that it is required for different AML cell types through its association with key transcription factors.
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