生命学院学术报告

题目： Protein Translocation Channel In Action

报告人：Long Li

Postdoctoral Research Associate

Department of Cell Biology, Harvard Medical School (Boston, MA, U.S.A.)

时间：2017年1月9日13:00-14:00

地点：金光生命科学大楼411

摘要:

As a decisive step in the secretory pathway, protein translocation has been studied extensively for over 30 years. However, some of the fundamental questions remained unsolved, e.g. how highly diverse signal sequences of secretory proteins are recognized by the protein translocation channel and how protein translocation is driven by ATP hydrolysis. To answer these questions, I developed an in vivo system to assemble a translocation machinery that consisted of all three components required for protein translocation, the SecY channel, the SecA ATPase motor, and a peptide substrate that is being translocated. I determined the crystal structure of the machinery. The study uncovered a universal recognition mechanism of signal sequences.

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