william hill中文网、生命科学联合中心学术报告

题目：G1 cyclins link proliferation, pluripotency and differentiation of stem cells

报告人：Professor Peter Sicinski，MD，PhD

Harvard Medical School，Dana-Farber Cancer Institute

时间：2017年3月15日（星期三）上午10:00－11:00

地点：王克桢楼348会议室

邀请人：李程（62757281,lch3000@gmail.com）

Progression of mammalian cells through the G1 and S phases of the cell cycle is driven by D-type and E-type cyclins. According to the current dogma, at least one of these cyclin families must be present to allow cell proliferation. Here, we show that several cell types can proliferate in the absence of all G1 cyclins. However, upon ablation of G1 cyclins,embryonic stem (ES) cells attenuated their pluripotent characteristics, with majority of cells acquiring the trophectodermal cell fate. We established that G1 cyclins, together with their associated cyclin-dependent kinases (CDKs) phosphorylate and stabilize core pluripotency factors Nanog, Sox2 and Oct4. Treatment of murine ES cells, patient-derived glioblastoma tumor-initiating cells, or triple-negative breast cancer cells with a CDKinhibitor strongly decreased Sox2 and Oct4 levels. Our findings suggest that CDK  kinase-inhibition might represent an attractive therapeutic strategy by targeting glioblastoma tumor-initiating cells, which depend on Sox2 to maintain their tumorigenic potential.

Sicinski 教授是细胞周期循环研究领域的著名专家。利用遗传学基因工程技术，Sicinski教授的研究组在阐明细胞周期蛋白在组织发育中的作用方面作出了若干关键性发现；利用小鼠模型，Sicinski教授的研究组证明抑制细胞周期蛋白是有力的抗癌方法。目前，Sicinski教授的实验室正结合基因组学、蛋白组学和系统生物学的计算方法研究细胞周期蛋白在人类肿瘤生长过程中的作用。Sicinski教授毕业于波兰华沙医学院，获得医学博士和哲学博士学位。他曾在英国剑桥大学医学研究理事会（Medical Research Council）做访问学者两年。随后到美国麻省理工学院，在Weinberg教授实验室做博士后研究，并于1997年成为美国哈佛大学医学院副教授，开始在国际著名的Dana-Farber癌症研究所工作。2007年他晋升为美国哈佛大学医学院终身教授，目前是哈佛大学医学院遗传学教授。实验室论文：

The requirement for cyclin D function in tumor maintenance.Cancer Cell. 2012

A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers.Nature. 2011

Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen.Nature. 2010

Cyclin A is redundant in fibroblasts but essential in hematopoietic and embryonic stem cells.Cell. 2009

欢迎各位老师同学积极参加！