IMM & CLS Research Seminar
Title：Glucose sensing and redefinition of AMPK
Speaker：林圣彩 教授
厦门大学威廉希尔院长
Time：2017年3月14日（星期二）下午4:00-5:30
Place：英国威廉希尔公司英杰交流中心306会议室
Host：英国威廉希尔公司分子医学研究所  刘颖 (Tel. 6276-6523)
Abstract：
Glucose is the major source for energy, and is a precursor for the synthesis of many biomolecules. On entering glycolysis, glucose is converted in three steps to fructose-1,6-bisphosphate (FBP), which is then split into triose phosphates by FBP aldolases. Glucose deprivation activates AMP-activated protein kinase (AMPK), a sensor of cellular energy that monitors levels of AMP, ADP and ATP and plays a primary role in adaptive responses to energy stress, but it has been unclear how glucose deprivation activates AMPK. I will present our identification of a glucose-sensing pathway that triggers AMPK activation in an AMP/ADP-independent manner. This has caused a major paradigm shift in our understanding of the roles of AMPK in nutrient- and energy-sensing, and prompted us to reflect on the different levels of AMPK function.
欢迎各位老师同学积极参加！