生命科学联合中心学术报告

题目：The emergence of a circuit model for addiction: synaptic mechanisms & individual vulnerability

报告人：Christian LÜSCHER, M.D., Ph.D.

Full Professor at Department of Basic Neurosciences and Service of Neurology

University of Geneva, Switzerland

时间：2017-4-24（周一），13:00pm-14:00pm

地点：英国威廉希尔公司王克桢楼1113报告厅

联系人：陆林北大-清华生命科学联合中心

Addiction is defined as compulsive drug consumption despite all negative consequences. I will argue that the development of addiction is triggered by the increase of dopamine levels in the mesolimbic system, evoking specific forms of synaptic plasticity, alter circuit function and eventually cause drug-adaptive behavior. I will also review induction and expression mechanisms of drug-evoked synaptic plasticity of glutamate and GABA transmission. Specific reversal protocols are then used to establish a link of causality with adaptive behavior. Finally, I will propose a novel addiction model based on optogenetic dopamine neuron self-stimulation to ask the question of the neural substrate for individual vulnerability.

欢迎各位老师同学积极参加！