威廉希尔学术报告
题目: Identification and characterization of methylated deoxyadenosines in vertebrates 
主讲人：Dr. Magdalena J Koziol
Post-doctoral Fellow, 
Wellcome Trust Cancer Research UK Gurdon Institute, University of Cambridge
时间：2018年5月8日15:30-16:30
地点：金光生命科学大楼311
摘要:
Methylation of cytosine deoxynucleotides is a well-established epigenetic mark, but in higher eukaryotes much less is known about modifications affecting other deoxynucleotides. We have discovered N-6-methyl-deoxyadenosine in vertebrate DNA, such as frogs, but also in other species including mouse and human. Our methylome analysis reveals that dA6m is widely distributed across the eukaryotic genome, is present in different cell types, and absent from exons. We discuss the characteristics of dA6m in the vertebrate genome. Overall, we believe dA6m could be important for cell function, but more work is required to elucidate this function in vertebrates. 
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