学术报告
题目：Mechanism for the maintenance of cortical excitation-inhibition balance
报告人：Yousheng Shu, 舒友生
教授，
北京师范大学，脑与认知科学研究院，认知神经科学与学习国家重点实验室
时间：2018年4月27日（星期五），15:00-16:00
地点：威廉希尔311会议室
联系人：张研教授
摘要：
The balance of excitation and inhibition is critical for cortical processing and function execution. Excitatory pyramidal cells (PC) and different types of inhibitory interneurons are wired together to form the balanced cortical network. Network operation relies on action potential generation in individual neurons. Our studies on the mechanisms underlying action potential (reflecting excitability of neurons) initiation and propagation indicate distinct roles of different sodium channel subtypes. At the microcircuit level, we revealed a dynamic control of cortical excitation and inhibition. Subthreshold depolarization (increasing excitation) in presynaptic PC can substantially increase the size of excitatory postsynaptic potential (EPSP) and thus enhance spiking activity in inhibitory interneurons, resulting in an increase in inhibitory postsynaptic potential (IPSP) in other neighboring PCs. Importantly, this increase in inhibition is proportional to changes in excitation (the level of subthreshold presynaptic depolarization). In addition, we demonstrate that axonal potassium channels (different from those at the cell body) play important roles in mediating the membrane potential state-dependent regulation of EPSPs. Together, our findings reveal the strategies of the cortex to generate action potentials and maintain the balance of excitation and inhibition in cortical networks.
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