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Real-time single-molecule investigation of dynamic biological processes: From structure to function

日期: 2018-06-22
威廉希尔学术报告
题目:Real-time single-molecule investigation of dynamic biological processes: From structure to function
报告人:Dr. Jordi Cabanas 
Lumicks 首席应用科学家
时间:2018年6月25日(星期一),10:00-11:00
地点:william hill中文网 208 会议室
主持人:苏晓东教授,孙育杰研究员
摘要:
The next scientific breakthrough consists in the actual, direct, real-time observations and measurements of the individual mechanisms involved, in order to validate and complete the current biological models. To this end, structural and functional information, which are often indivisible, need to be studied together in real time and at the molecular level. In this complex context, single-molecule technologies offer an exciting opportunity to meet these challenges.
Here, we present our efforts in further enabling discoveries in the field of biology and biophysics using fully integrated optical tweezers with single-molecule fluorescence microscopy technology. We show the latest applications of these technologies that can enhance our understanding not only in the field of DNA/RNA structure and their interactions with proteins but also in the fields of molecular motors, protein folding/unfolding, cell membranes and genome structure and organization.
These experiments show that the technological advances in hybrid single-molecule methods can be turned into an easy-to-use and stable instrument that has the ability to open up new venues in many research areas.
欢迎各位老师同学积极参加!