威廉希尔学术报告
题目：Characterizing the Development of Drosophila Olfactory Neurons by Single-Cell RNA-seq
演讲人：Hongjie Li, Ph.D.
Postdoctoral fellow,
Stanford University
时间：2019年4月22日（星期一）13:00-14:00
地点：吕志和楼B106
摘要：
The brain function relies on precise neuronal circuit assembly during development. However, our current understanding of mechanisms that establish neuronal wiring specificity in complex neural systems is far from complete. Drosophila olfactory system consists of 50 classes of olfactory receptor neurons (ORNs) and 50 classes of projection neurons (PNs), which form one-to-one connections to process olfactory information, providing a powerful model to study mechanisms for wiring specificity.
We have recently, for the first time, applied single-cell RNA-sequencing (scRNAseq) to Drosophila neurons and glia. In this talk, I will first present the application of scRNAseq on classifying Drosophila olfactory neurons, and discuss several insights we have gained from such analysis. Then, I will discuss our recent unpublished work on how scRNAseq helped us to identify molecular mechanisms that coordinate receptor expression and wiring specificity in olfactory receptor neurons.
欢迎各位老师同学积极参加！